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What Repaglinide is and how it works

Repaglinide is a meglitinide, a type of insulin secretagogue. It works by helping your pancreas release insulin after meals.

It is used to lower blood sugar in adults with type 2 diabetes.

Repaglinide acts quickly after you take it. It closes ATP‑dependent potassium channels in the insulin‑producing cells of the pancreas, which makes these cells release more insulin. The extra insulin helps move glucose from your blood into your body's cells after you eat.

Common medical uses

Repaglinide is used with diet and exercise to control blood sugar in adults with type 2 diabetes. It can be added when diet and exercise alone do not reach the target.

In some cases, your doctor may use repaglinide with other diabetes medicines. Do not switch from one medicine to another without medical advice.

Repaglinide is not for type 1 diabetes or for treating diabetic ketoacidosis. It is a supplemental therapy that helps cover meals.

How it is typically taken

Take repaglinide right before meals, or up to 15 minutes before a meal. The timing helps the medicine match the rise in blood sugar that comes with eating.

If you skip a meal, skip the dose for that meal. Do not take extra pills to cover a missed meal. Your doctor may guide you if meals are irregular.

Take with a full glass of water. Do not crush or chew the tablet.

Important safety information

Repaglinide can cause low blood sugar. This risk rises if you eat less than planned, skip meals, drink alcohol, or use certain medicines. Learn the signs: sweating, shaking, fast heartbeat, dizziness, or confusion.

Tell your doctor about liver problems. Your dose may be adjusted, and long‑term use requires monitoring. It can interact with many medicines, including antibiotics, antifungals, and some diabetes drugs.

Pregnant or breastfeeding? Talk to your clinician before use. If you have kidney or liver disease, you may need a dose change or closer monitoring.

Common side effects

Common side effects include low blood sugar. This may feel like hunger, shakiness, sweating, or faintness. Having a snack or meal often helps.

Weight gain, headache, dizziness, and upset stomach are also reported. Some people have runny nose, sore throat, back pain, or changes in mood.

Seek medical help for severe reactions or signs of allergy, such as swelling, trouble breathing, or a severe skin rash. If you notice yellowing of the skin, dark urine, or pale stools, tell your clinician right away.